Impact on backpropagation of the spatial heterogeneity of sodium channel kinetics in the axon initial segment.
In a variety of neurons, action potentials (APs) initiate at OTF Automatic the proximal axon, within a region called the axon initial segment (AIS), which has a high density of voltage-gated sodium channels (NaVs) on its membrane.In pyramidal neurons, the proximal AIS has been reported to exhibit a higher proportion of NaVs with gating properties t